Senin, 06 Februari 2017

Prehistoric Diseases, Common Cause of Death, and Human Lifespan

Monday, February 6, 2017

I remember how fun it was, being alone at my room back in college, reading encyclopedia, jumping from one topic to another. I wasn’t really addicted to Google or anything on the internet. In fact, it was almost 2010 and I only used internet to send e-mail or looking for some images I needed for my homework.

But when I started to use social media, I became addicted to the internet and social media. And my blog, part of the social media, has always been all about me. It’s actually because I have many blogs for so many things. But then I’m too lazy to continue writing those blogs, and only post in this diary, so, of course almost everything here is about me. Yes, I’m still enjoying browsing for scientific, historic things, but I never write any of it on this blog.

I only keep the miscellaneous in my private notes in my computer. But now that my computer seems to be dying, I wanna start writing some notes here, just for back up, just in case.

Anyway, lately I’ve been reading some articles about the Lower and Upper Palaeolithic Europe, and suddenly these questions just popped out in my mind:
1. What is the most ancient disease in medical history?
2. What is the most common cause of prehistoric death?
3. How long is the lifespan of most prehistoric humans?



So I found some articles, and I’ll just write down all my conclusions from those articles. To read the complete articles, just check on the links.

First question, what is the most ancient disease in medical history? What about… top 10 most ancient diseases instead?
This is from one of my favorite sites: science.howstuffworks.com

10 Oldest Diseases in History:

Some archeologists have found some of the most ancient diseases by analyzing the bones, DNA, and whatever left from the prehistoric human remains. And here is the list of Top 10 Oldest Diseases in History:

10 > Cholera (dated 400 BCE, Greece and India)
Cholera can be found on the list of diseases catalogued by the Athenian physician Hippocrates in 400 BCE. Cholera itself has been existing far before Hippocrates. This disease originated in the Ganges River that happens to be one of the most ancient locations of human population density. Cholera lives in the world’s water sources.

9 > Typhoid Fever (430 to 426 BCE, Greece)
A great plague swept through the city-state of Athens, by the description from the historian Thucydides, has the same symptoms with Typhoid Fever.
“People in good health were all of a sudden attacked by violent heats in the head and the throat or tongue, becoming bloody and emitting an unnatural and fetid breath. When it fixed in the stomach, it upset it; and discharges of bile of every kind named by physicians ensued, accompanied by very great distress. If they passed this stage, and the disease descended further into the bowels, inducing a violent ulceration there accompanied by severe diarrhea, this brought on a weakness which was generally fatal.
The disease couldn't have come at a worse time. The plague contributed to Athens' eventual loss to Sparta in the Peloponnesian War and a long hiatus for democracy in world history.”

8 > Leprosy (dated 1550 BCE, Egypt)
The Egyptian "Ebers Papyrus," written in 1550 B.C.E., which recommends, "If you examine a large tumor of Khonsu in any part of a man and it is terrible and it has made many swellings. Something has appeared in it like that in which there is air ... Then you shall say concerning it: It is a swelling of Khonsu. You should not do anything against it" [source: Nunn].
And here’s the scariest part of Leprosy:
“While typhoid and cholera are fairly straightforward in their aggressive spread through water sources, leprosy relies on another dispersion strategy -- that of dormancy. People can carry the bacteria that cause leprosy for 20 years or more before showing symptoms, and during this time can spread the disease.”

7 > Smallpox (dated 1580 BCE, Egypt)
Generally, the goal of mummification is to preserve soft tissue. So, as you would expect, Egypt provides a treasure trove of information on ancient, soft tissue diseases.
The most ancient of these mummies was dated 1580 B.C.E., and the most recent was the mummy of Ramses V, who died in 1157 B.C.E.
Smallpox is one of history's greatest killers, responsible for 300 to 500 million deaths in the 20th century [source: Saint Louis University].

6 > Rabies (dated 2300 BCE, Babylon)
Rabies is ingenious: Not only does it infect a host, but it also hijacks the host's brain in a way that makes the host want to bite things. This is how rabies gets a ticket to ride. And it's been doing it since at least 2300 B.C.E., when it was described in the Eshuma Code of Babylon [source: Rupprecht et al.].

5 > Malaria (dated 2700 BCE, China)
Granted, that statistic extends the origin of the disease back in time past its first definite mention, which was in the Chinese "Nei Ching" ("The Canon of Medicine"), around the year 2700 B.C.E. [source: CDC].
The disease continues to infect 300 million people every year, killing 1 million of them [source: Shah].
The Wall Street Journal reports that malaria is responsible for half of all human deaths since the Stone Age [source: Shah].

4 > Pneumonia
Hippocrates wrote that fluid in the lungs should be called pneumonia if, "the fever be acute, and if there be pains on either side, or in both, and if expiration be if cough be present, and the sputa expectorated be of a blond or livid color" [source: Hippocrates]. But he also distinctly calls it a "disease of the ancients."
Where exactly does pneumonia place in this list of oldest known diseases? Because it's a soft tissue disease, the archaeological record isn't strong. But it's likely that various forms of pneumonia have been around as long as our lungs.

3 > Trachoma (8,000 BCE, Australia)
“Trachoma is a chronic infection of the upper eyelid that eventually results in the eyelid constricting and turning the eyelashes in toward the cornea. Over time, the rubbing of the constricted eyelid and especially the eyelash makes the patient go blind. This is what happened to Aetius, Paulus Aeginetus, Alexander, Trailaus, Horace and Cicero. And trachoma is described in Hippocrates and in the Egyptian Ebers papyrus [sources: Siniscal and Nunn].
But researchers make a compelling case for earlier trachoma found in a corner of the world little associated with early diseases: Australia. Aboriginal skeletons from 8000 B.C.E. show a common skull lesion around the eyes [source: Webb]. Scientists determined that these lesions were due to bone infection that had come from soft tissue infection. Though there are a few eye diseases that could fit this bill, the skeletons were found in the Australian region in which trachoma is most common today.”

2 > TBC (500,000 years ago, Turkey)
In 2008, a team of scientists from University College London excavated the submerged ancient city of Alit-Yam, off the coast of Israel. There, they found the buried remains of a mother and her child. Both skeletons showed bone lesions characteristic of tuberculosis [source: Lloyd]. DNA testing confirmed it: Tuberculosis is at least 9,000 years old.
While the Alit-Yam finding is the oldest confirmed case of TB, characteristic lesions have been found on bones found in Turkey, dated about 500,000 years ago [source: Lloyd].

1 > Rocky Mountain Spotted Fever (as long as the history of human and animals cells)
“Mitochondria are small organelles found in nearly every cell in the human body. And they perform a function essential to human life, converting glucose from food to energy called adenosine triphosphate, or ATP, which cells can use.
But mitochondria carry their own genetic material -- separate from human DNA -- and these genes look a lot like those of bacteria. In other words, it's very likely that the mitochondria that we depend on for survival are the products of an ancient infection [source: Andersson et al.].
Whatever the infection, it predates animal life, let alone humans. So there's no use exploring the fossil record. Instead, researchers compared the genes of mitochondria to those of existing bacteria. The closest match was to bacteria of order Rickettsiales, many of which cause diseases -- including Rocky Mountain spotted fever [sources: Eremeeva and Dasch, Andersson et al.].
But remember, we're talking about a disease that existed before animal life. So the oldest disease isn't really Rocky Mountain Spotted Fever itself, but some unnamed proto-disease with genetic similarity.
Long, long ago bacteria invaded a cell. And because of this infection, we have life as we know it.



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Second question: what is the most common cause of prehistoric death?

So I’ve found this interesting journal in this link:
And they even happened to have the comparison between the prehistoric human and the present human. It’s a very interesting journal! You really should check!

Modern Humans and Disease, Highly Developed Countries:
- Life expectancy has increased from ~50 yrs in 1950 to 86 years in 2000. For the first time in history a mother knows that the loss of one of her children before maturity is an unlikely event.
- Main causes of death are non-communicable diseases (cancer, obesity, diabetes, hypertension).
- Food plentiful, sedentary lifestyle.
- Acute infections decline because of improved public health information, vaccines, medical treatments, and increased resistance to infection due to nourishment

Early Humans and Disease, domestication of plants and animals (~6000 years ago):
- Creation of first !urban" areas with large populations in continuous close contact. Increase in food supply and expansion of populations.
- Main causes of death were accidents, food shortage, predation, infectious disease, with increases in communicable diseases: TB, Measles, Smallpox, Leprosy, Polio
- Diet was different from that of hunter-gatherer, but still based mainly on unrefined plant foods.
- Non-communicable diseases (cancer, obesity, diabetes, hypertension) were rare to non-existent.

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And finally…, the last question: how long is the lifespan of most prehistoric humans?

I found this article with very amazing facts in Wikipedia:
So they have medicine, even before writing existed! Wow! This is really amazing!



And by the way, how long is the lifespan of prehistoric humans? Here’s what is written in the page:
“The life expectancy in prehistoric times was low, 25–40 years, with men living longer than women; archaeological evidence of women and babies found together suggests that many women would have died in childbirth, perhaps accounting for the lower life expectancy in women than men. Another possible explanation for the shorter life spans of prehistoric humans may be malnutrition; also, men as hunters may have sometimes received better food than the woman, who would consequently have been less resistant to disease.”

Wow! 25 to 40 years old!? Can you imagine? Humans lifespan used to be that short!

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Here’s some other interesting links:

Timeline of Medicine and Medical Technology (from 3300 BC to present):

History of Medicine:

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